PRSS2
Sign in to saveAlso known as TRY2, TRY8, TRYP2, protease, serine 2, serine protease 2
Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.
Gene data
PRSS2- Name
- serine protease 2
- Type
- protein-coding
- Position
- 142,760,398–142,774,564 (+)
- Aliases
- TRY2, TRY8, TRYP2
- Ensembl
- ENSG00000275896
- RefSeq RNA
- NM_001303414.2, NM_002770.4, NR_130149.2, XM_054358659.1
- RefSeq protein
- NP_001290343.1, NP_002761.1, XP_054214634.1
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
serine protease 2
- Symbol
- PRSS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR7_2_CTG6:793,943-797,532
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.
== Function ==
Excerpted from Wikipedia’s “PRSS2” article, available under the CC BY-SA 4.0 licence.