pseudohypoaldosteronism
Sign in to saveAlso known as Renal tubular acidosis, distal, type 4, Hyperkalemic distal renal tubular acidosis
Pseudohypoaldosteronism (PHA) is a condition that mimics hypoaldosteronism (presenting hyperkalemia). Two major types of primary pseudohypoaldosteronism are recognized and these have major differences in etiology and presentation.
Key facts
- Medical condition (new).name
- Pseudohypoaldosteronism Type 1
- Medical condition (new).image
- Aldosterone-2D-skeletal.svg
- Medical condition (new).caption
- In pseudohypoaldosteronism type 1, aldosterone is elevated (hyperaldosteronism), but because the body fails to respond to it, it appears similar to hypoaldosteronism.
- Medical condition (new).symptoms
- Failure to thrive, dehydration, hyponatremia, metabolic acidosis, hyperkalemia, and other non-specific symptoms including nausea, vomiting, extreme fatigue, and muscle weakness.
- Medical condition (new).causes
- Mutations in the NR3C2, SCNN1A, SCNN1B, or SCNN1G genes
via Wikipedia infobox
Research
1,014 papers- Pseudohypoaldosteronism.Endocrine development · 2013
- Transient pseudohypoaldosteronism: a potentially severe condition affecting infants with urinary tract malformation.Journal of pediatric urology · 2019
- [Pseudohypoaldosteronism].Nihon rinsho. Japanese journal of clinical medicine · 1996
- Pseudohypoaldosteronism and mineralocorticoid receptor abnormalities.The Journal of steroid biochemistry and molecular biology · 1991
- Pulmonary manifestations of Pseudohypoaldosteronism type 1b: A systematic review of the literature.Paediatric respiratory reviews · 2025
via PubMed
~10 min read
Encyclopedic overview
20 sectionsContents
- Pseudohypoaldosteronism type 1 (PHA1)
- Mechanism
- Onset
- Symptoms
- Types
- Treatment
- Risks
- Pseudohypoaldosteronism type 2 (PHA2)
- Mechanism
- Onset
- Symptoms
- Types
- Treatment
- Risks
- Pregnancy risks
- Other risks
- History
- See also
- References
- External links
Pseudohypoaldosteronism (PHA) is a condition that mimics hypoaldosteronism (presenting hyperkalemia). Two major types of primary pseudohypoaldosteronism are recognized and these have major differences in etiology and presentation.
== Pseudohypoaldosteronism type 1 (PHA1) ==
Excerpted from Wikipedia’s “pseudohypoaldosteronism” article, available under the CC BY-SA 4.0 licence.