PSMD10
Sign in to saveAlso known as dJ889N15.2, p28, p28(GANK), proteasome 26S subunit, non-ATPase 10
26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. First isolated in 1998 by Tanaka et al.; Gankyrin is an oncoprotein that is a component of the 19S regulatory cap of the proteasome. Structurally, it contains a 33-amino acid ankyrin repeat that forms a series of alpha helices. It plays a key role in regulating the cell cycle via protein-protein interactions with the cyclin-dependent kinase CDK4. It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma protein, bo
Gene data
PSMD10- Name
- proteasome 26S subunit, non-ATPase 10
- Type
- protein-coding
- Chromosome
- X
- Position
- 108,084,202–108,091,619 (−)
- Aliases
- dJ889N15.2, p28, p28(GANK)
- Ensembl
- ENSG00000101843
- RefSeq RNA
- NM_002814.4, NM_170750.3
- RefSeq protein
- NP_002805.1, NP_736606.1
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein PSMD10 PDB 1qym.png
Show 5 more facts
- HomoloGene ID
- 94517
- exact match
- identifiers.org/ncbigene/5716
- genomic end
- 108091549
- genomic start
- 107327437
- cytogenetic location
- Xq22.3
Sources (3)
via Wikidata · CC0
~6 min read
Article
6 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. First isolated in 1998 by Tanaka et al.; Gankyrin is an oncoprotein that is a component of the 19S regulatory cap of the proteasome. Structurally, it contains a 33-amino acid ankyrin repeat that forms a series of alpha helices. It plays a key role in regulating the cell cycle via protein-protein interactions with the cyclin-dependent kinase CDK4. It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma protein, both transcription factors involved in tumor suppression and found mutated in many cancers. Gankyrin also has an anti-apoptotic effect and is overexpressed in certain types of tumor cells such as hepatocellular carcinoma.
== Function ==