ranpirnase
Sign in to saveAlso known as Amphinase-2, Onconase
Ranpirnase is a ribonuclease enzyme found in the oocytes of the Northern Leopard Frog (Rana pipiens). Ranpirnase is a member of the pancreatic ribonuclease (RNase A) protein superfamily and degrades RNA substrates with a sequence preference for uracil and guanine nucleotides. Along with amphinase, another leopard frog ribonuclease, Ranpirnase has been studied as a potential cancer and antiviral treatment due to its unusual mechanism of cytotoxicity tested against transformed cells and antiviral activity.
Protein · UniProt
Amphinase-2
- Organism
- Lithobates pipiens (Northern leopard frog)
- Length
- 114 aa
- Molecular mass
- 13,085 Da
- Evidence
- 1: Evidence at protein level
Endonuclease, hydrolyzes highly polymerized RNA, poly(U) and poly(C), and the dinucleotides CpA and UpA. Hydrolyzes 18S and 28S ribosomal RNA. More active towards rCA than rUA or rUG. Has cytotoxic activity against cultured human submaxillary gland carcinoma cells
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
4 registered- NOT_YET_RECRUITINGNeoadjuvant Treatment of Breast CancerNational Institute of Oncology, Hungary · NCT05131893
- PHASE3UNKNOWNONCONASE Plus Doxorubicin Versus Doxorubicin Alone For Patients With Malignant Pleural or Peritoneal Mesothelioma Who Have Had No More Than One Prior Chemotherapy RegimenAlfacell · NCT00003034
- PHASE2WITHDRAWNA Study Of Ranpirnase(Onconase®) To Pemetrexed Plus Carboplatin In Patients With Non-Squamous Non-Small Cell Lung CancerTamir Biotechnology, Inc. · NCT01184287
- PHASE1/PHASE2COMPLETEDSafety and Efficacy Study of Topical Ranpirnase to Treat Genital Warts (HPV)Tamir Biotechnology, Inc. · NCT02535104
Wikidata facts
- Instance of
- protein
Show 2 more facts
- found in taxon
- Lithobates pipiens
- Commons category
- Ranpirnase
via Wikidata · CC0
~6 min read
Encyclopedic overview
8 sectionsContents
- EC number
- Reaction pathway
- Structure
- Function
- Known crystal structures
- Known active sites
- Structure tied to function
- References
Ranpirnase is a ribonuclease enzyme found in the oocytes of the Northern Leopard Frog (Rana pipiens). Ranpirnase is a member of the pancreatic ribonuclease (RNase A) protein superfamily and degrades RNA substrates with a sequence preference for uracil and guanine nucleotides. Along with amphinase, another leopard frog ribonuclease, Ranpirnase has been studied as a potential cancer and antiviral treatment due to its unusual mechanism of cytotoxicity tested against transformed cells and antiviral activity.
Ranpirnase was originally discovered by scientists at TamirBio, a biotechnology company (formerly Alfacell Corporation), where it was tested in preclinical assays and in clinical trials under the name Pannon or Onconase, and TMR004. The mechanism of action of ranpirnase has been attributed to the RNA interference pathway, potentially through cleaving siRNA molecules; to cleavage of transfer RNA; and to interference with the NF-κB pathway. Currently (as of March 2020) Ranpirnase is in clinical trials as a potential antiviral.
Excerpted from Wikipedia’s “ranpirnase” article, available under the CC BY-SA 4.0 licence.