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GeneQ18031049· pop 5· linked from 4 articles

RASGRF1

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Also known as CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.

Gene data

RASGRF1
Name
Ras protein specific guanine nucleotide releasing factor 1
Type
protein-coding
Position
78,959,906–79,090,930 (−)
Aliases
CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1
Ensembl
ENSG00000058335
RefSeq RNA
NM_001145648.3, NM_002891.6, NM_153815.3, XM_011521866.4, XM_017022455.3
RefSeq protein
NP_001139120.1, NP_002882.3, NP_722522.1, XP_011520168.1, XP_016877944.1

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].

Gene Ontology

Pathways

MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Focal adhesion - Homo sapiens (human)Neurotransmitter receptors and postsynaptic signal transmissionTransmission across Chemical SynapsesNeuronal SystemSignal TransductionPost NMDA receptor activation eventsCREB1 phosphorylation through NMDA receptor-mediated activation of RAS signalingActivation of NMDA receptors and postsynaptic events

via MyGene.info

Gene · Ensembl

Ras protein specific guanine nucleotide releasing factor 1

Symbol
RASGRF1
Biotype
Protein coding
Organism
Homo sapiens
Location
15:78,959,906-79,090,930
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

Excerpted from Wikipedia’s “RASGRF1” article, available under the CC BY-SA 4.0 licence.

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