RNF34
Sign in to saveAlso known as CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to RNF34, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.
It sits within the topics Genes on human chromosome 12 and RING finger proteins.
Vinony links it to 4 Wikipedia language editions.
Gene data
RNF34- Name
- ring finger protein 34
- Type
- protein-coding
- Position
- 121,400,078–121,446,466 (+)
- Aliases
- CARP-1, CARP1, RFI, RIF, RIFF, hRFI
- Ensembl
- ENSG00000170633
- RefSeq RNA
- NM_001256858.2, NM_001394208.1, NM_025126.4, NM_194271.3, NR_172087.1
- RefSeq protein
- NP_001243787.1, NP_001381137.1, NP_079402.2, NP_919247.1, XP_024304959.1
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ring finger protein 34
- Symbol
- RNF34
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:121,400,078-121,446,466
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 11839
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/80196
- chromosome
- human chromosome 12
- genomic start
- 121400083
- genomic end
- 121868389
- cytogenetic location
- 12q24.31
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Excerpted from Wikipedia’s “RNF34” article, available under the CC BY-SA 4.0 licence.