RNH1

Name

ribonuclease/angiogenin inhibitor 1

Type

protein-coding

Aliases

IIAE12, RAI, RNH

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010].

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Gene · Ensembl

ribonuclease/angiogenin inhibitor 1

Symbol

RNH1

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR11_1_CTG8:24,153-36,941

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein RNH1 PDB 1a4y.png

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