RNH1

Also known as RAI, RNH, ribonuclease/angiogenin inhibitor 1

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.

Gene data

RNH1

Name: ribonuclease/angiogenin inhibitor 1
Type: protein-coding
Position: 494,510–507,395 (−)
Aliases: IIAE12, RAI, RNH
Ensembl: ENSG00000023191
RefSeq RNA: NM_002939.4, NM_203383.2, NM_203384.2, NM_203385.2, NM_203386.3
RefSeq protein: NP_002930.2, NP_976317.1, NP_976318.1, NP_976319.1, NP_976320.1

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010].