RPA2

Also known as REPA2, RP-A p32, RP-A p34, RPA32, replication protein A2

protein-coding gene in the species Homo sapiens

Gene data

RPA2

Name: replication protein A2
Type: protein-coding
Position: 27,891,524–27,914,751 (−)
Aliases: REPA2, RP-A p32, RP-A p34, RPA32
Ensembl: ENSG00000117748
RefSeq RNA: NM_001286076.2, NM_001297558.1, NM_001355128.2, NM_001355129.2, NM_002946.5
RefSeq protein: NP_001273005.1, NP_001284487.1, NP_001342057.1, NP_001342058.1, NP_002937.1

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017].