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GeneQ18031325· pop 5· linked from 2 articles

RREB1

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Also known as FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1

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Gene data

RREB1

Name: ras responsive element binding protein 1
Type: protein-coding
Position: 7,107,418–7,251,982 (+)
Aliases: FINB, HNT, LZ321, RREB-1, Zep-1
Ensembl: ENSG00000124782
RefSeq RNA: NM_001003698.4, NM_001003699.4, NM_001003700.2, NM_001168344.2, NM_002955.4
RefSeq protein: NP_001003698.1, NP_001003699.1, NP_001003700.1, NP_001161816.1

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of epithelial cell migration positive regulation of mammary gland epithelial cell proliferation positive regulation of DNA-templated transcription

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity

Cellular component

nucleus nucleus cytoplasm nuclear body nuclear speck nuclear speck nuclear speck extracellular exosome

via MyGene.info

Gene · Ensembl

ras responsive element binding protein 1

Symbol: RREB1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:7,107,418-7,251,982
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 2218
chromosome: human chromosome 6
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6239
genomic end: 7252213
genomic start: 7107830
cytogenetic location: 6p24.3

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Clinical significance
References
Further reading

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.

== Clinical significance ==

Excerpted from Wikipedia’s “RREB1” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0