S100A12

Also known as CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6, S100 calcium binding protein A12

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. Human S100A12, also known as calgranulin C, was first described in 1995.

Gene data

S100A12

Name: S100 calcium binding protein A12
Type: protein-coding
Position: 153,373,711–153,375,621 (−)
Aliases: CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6
Ensembl: ENSG00000163221
RefSeq RNA: NM_005621.2
RefSeq protein: NP_005612.1

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014].

Pathways

Cytokine Signaling in Immune system Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 7/8 (TLR7/8) Cascade

via MyGene.info

Gene · Ensembl

S100 calcium binding protein A12

Symbol: S100A12
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:153,373,703-153,375,660
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein S100A12 PDB 1e8a.png

Show 5 more facts

HomoloGene ID: 48361
exact match: identifiers.org/ncbigene/6283
genomic end: 153375621
genomic start: 153373711
cytogenetic location: 1q21.3

Sources (3)

via Wikidata · CC0

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Article

5 sections

Contents

Function
Tissue distribution
Clinical significance
References
Further reading

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. Human S100A12, also known as calgranulin C, was first described in 1995.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.