SDC4
Sign in to saveAlso known as SYND4, syndecan 4
Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in
Gene data
SDC4- Name
- syndecan 4
- Type
- protein-coding
- Position
- 45,325,288–45,348,433 (−)
- Aliases
- SYND4
- Ensembl
- ENSG00000124145
- RefSeq RNA
- NM_002999.4, XM_011528977.3, XM_054323804.1
- RefSeq protein
- NP_002990.2, XP_011527279.1, XP_054179779.1
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
syndecan 4
- Symbol
- SDC4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:45,325,288-45,348,433
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
8 sectionsContents
- Gene
- Function
- Clinical significance
- [[Endometriosis]]
- Osteoarthritis
- References
- Further reading
- External links
Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules.
Syndecans have similar structural features: Attach to heparan sulfate chains – interacting factors (e.g. Matrix molecules, growth factors, and enzymes) Chondroitin sulfate chain Transmembrane domain – self-association C1 domain – actin-association cytoskeleton Variable domain – syndecan-specific C2 domain – attach to PDZ proteins
Excerpted from Wikipedia’s “SDC4” article, available under the CC BY-SA 4.0 licence.