Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene.
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
via MyGene.info
Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene.
==Clinical relevance== A mutation in this gene in Finnish Hound dogs have been implicated in cases of cerebellar ataxia. Mutant cells suffer disruptions in their endoplasmic reticula, leading to disease.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).