SESN1
Sign in to saveAlso known as PA26, SEST1, sestrin 1
Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the
Gene data
SESN1- Name
- sestrin 1
- Type
- protein-coding
- Position
- 108,984,309–109,095,097 (−)
- Aliases
- PA26, SEST1
- Ensembl
- ENSG00000080546
- RefSeq RNA
- NM_001199933.2, NM_001199934.2, NM_014454.3
- RefSeq protein
- NP_001186862.1, NP_001186863.1, NP_055269.1
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sestrin 1
- Symbol
- SESN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:108,984,309-109,095,097
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 8697
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27244
- genomic end
- 109094846
- genomic start
- 108984309
- chromosome
- human chromosome 6
- cytogenetic location
- 6q21
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
== See also== SESN2
Excerpted from Wikipedia’s “SESN1” article, available under the CC BY-SA 4.0 licence.