SESN3
Sign in to saveAlso known as SEST3, sestrin 3
Sestrin 3 is a protein that in humans is encoded by the SESN3 gene.
Gene data
SESN3- Name
- sestrin 3
- Type
- protein-coding
- Position
- 95,165,513–95,232,541 (−)
- Aliases
- SEST3
- Ensembl
- ENSG00000149212
- RefSeq RNA
- NM_001271594.2, NM_144665.4, XM_011542614.2, XM_024448355.2, XM_047426416.1
- RefSeq protein
- NP_001258523.1, NP_653266.2, XP_011540916.1, XP_024304123.1, XP_047282372.1
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
sestrin 3
- Symbol
- SESN3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:95,165,513-95,232,541
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 14386
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/143686
- genomic end
- 94965705
- genomic start
- 94898704
- chromosome
- human chromosome 11
- cytogenetic location
- 11q21
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Sestrin 3 is a protein that in humans is encoded by the SESN3 gene.
==Function==
Excerpted from Wikipedia’s “SESN3” article, available under the CC BY-SA 4.0 licence.