SF3A1
Sign in to saveAlso known as PRP21, PRPF21, SAP114, SF3A120, splicing factor 3a subunit 1
Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.
Gene data
SF3A1- Name
- splicing factor 3a subunit 1
- Type
- protein-coding
- Position
- 30,331,988–30,356,919 (−)
- Aliases
- PRP21, PRPF21, SAP114, SF3A120
- Ensembl
- ENSG00000099995
- RefSeq RNA
- NM_001005409.1, NM_005877.6
- RefSeq protein
- NP_005868.1
This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
splicing factor 3a subunit 1
- Symbol
- SF3A1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:30,331,988-30,356,919
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “SF3A1” article, available under the CC BY-SA 4.0 licence.