SH3BGRL3
Sign in to saveAlso known as HEL-S-297, SH3BP-1, TIP-B1, SH3 domain binding glutamate rich protein like 3
SH3 domain-binding glutamic acid-rich-like protein 3 is a protein that in humans is encoded by the SH3BGRL3 gene.
Gene data
SH3BGRL3- Name
- SH3 domain binding glutamate rich protein like 3
- Type
- protein-coding
- Aliases
- HEL-S-297, SH3BP-1, TIP-B1
Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
SH3 domain binding glutamate rich protein like 3
- Symbol
- SH3BGRL3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:26,279,128-26,281,522
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein SH3BGRL3 PDB 1j0f.png
Show 5 more facts
- HomoloGene ID
- 41824
- exact match
- identifiers.org/ncbigene/83442
- genomic end
- 26608007
- genomic start
- 26280086
- cytogenetic location
- 1p36.11
Sources (4)
via Wikidata · CC0
~2 min read
Article
3 sectionsContents
- Role in cancer
- References
- Further reading
SH3 domain-binding glutamic acid-rich-like protein 3 is a protein that in humans is encoded by the SH3BGRL3 gene.
The 10.5kDa protein SH3 binding glutamic acid-rich protein-like 3 has an isoelectric point of 5.0. SH3 binding glutamic acid-rich (SH3BGR) gene is located to human chromosome 21. Two homologous genes, SH3BGRL and SH3BGRL3 are located to chromosome Xq13.3 and 1p34.3-35, respectively and code for small proteins similar to the N-terminal region of the SH3BGR protein. SH3BGRL3 protein shows a significant similarity to glutaredoxin 1 of E. coli, and all the three proteins are predicted to belong to thioredoxin-like protein family. Glutaredoxins (GRXs) are ubiquitous oxidoreductases, which catalyze the reduction of many intra-cellular protein disulfides and play an important role in many redox pathways. However, the SH3BGRL3 protein lacks the enzymatic function of glutaredoxins and may have a role as a regulator of redox activity.