Gene data
SIRT5- Name
- sirtuin 5
- Type
- protein-coding
- Position
- 13,512,411–13,615,158 (+)
- Aliases
- SIR2L5
- Ensembl
- ENSG00000124523
- RefSeq RNA
- NM_001193267.2, NM_001242827.1, NM_001376798.1, NM_001376799.1, NM_001376800.1
- RefSeq protein
- NP_001180196.1, NP_001229756.1, NP_001363727.1, NP_001363728.1, NP_001363729.1
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sirtuin 5
- Symbol
- SIRT5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:13,512,411-13,615,158
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SIRT5 PDB 2b4y.png
Show 8 more facts
- HomoloGene ID
- 40825
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23408
- genomic end
- 13614790
- genomic start
- 13574816
- chromosome
- human chromosome 6
- cytogenetic location
- 6p23
- expressed in
- biceps brachii
Sources (4)
via Wikidata · CC0