SLAMF6

Also known as CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

Gene data

SLAMF6

Name: SLAM family member 6
Type: protein-coding
Position: 160,485,030–160,523,273 (−)
Aliases: CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000
Ensembl: ENSG00000162739
RefSeq RNA: NM_001184714.2, NM_001184715.2, NM_001184716.2, NM_052931.5, XM_017000216.2
RefSeq protein: NP_001171643.1, NP_001171644.1, NP_001171645.1, NP_443163.1, XP_016855705.1

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].

Gene Ontology

Biological process

immune response positive regulation of type II interferon production positive regulation of interleukin-17 production T cell activation positive regulation of natural killer cell mediated cytotoxicity T-helper 17 cell lineage commitment

Molecular function

protein binding identical protein binding

Cellular component

plasma membrane plasma membrane plasma membrane external side of plasma membrane membrane extracellular exosome

Pathways

Adaptive Immune System Immune System Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

via MyGene.info

Wikidata facts

Image: Protein SLAMF6 PDB 2if7.png

Show 5 more facts

HomoloGene ID: 49945
exact match: identifiers.org/ncbigene/114836
genomic end: 160493052
genomic start: 160454820
cytogenetic location: 1q23.2-q23.3

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SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.