SMIM20
Sign in to saveAlso known as C4orf52, small integral membrane protein 20, MITRAC7, PNX
Small integral membrane protein 20 (SMIM20) is a protein that in humans is encoded by the SMIM20 gene. SMIM20 acts as a prohormone to the peptide hormone phoenixin (PNX) which was discovered for the first time in 2013 in rodent sensory ganglia. Two alternate cleavage sites within SMIM20 results in two different phoenixin products, Phoenixin-14 (PNX-14) and Phoenixin-20 (PNX-20).
Gene data
SMIM20- Name
- small integral membrane protein 20
- Type
- protein-coding
- Position
- 25,861,830–25,931,807 (+)
- Aliases
- C4orf52, MITRAC7, PNX
- Ensembl
- ENSG00000250317
- RefSeq RNA
- NM_001145432.3, NM_001394130.1
- RefSeq protein
- NP_001138904.1, NP_001381059.1
Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
small integral membrane protein 20
- Symbol
- SMIM20
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:25,861,830-25,931,807
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 82612
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/389203
- chromosome
- human chromosome 4
- genomic start
- 25863452
- genomic end
- 25929813
- cytogenetic location
- 4p15.2
- expressed in
- biceps brachii
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Receptor signaling
- See also
- References
- Further reading
Small integral membrane protein 20 (SMIM20) is a protein that in humans is encoded by the SMIM20 gene. SMIM20 acts as a prohormone to the peptide hormone phoenixin (PNX) which was discovered for the first time in 2013 in rodent sensory ganglia. Two alternate cleavage sites within SMIM20 results in two different phoenixin products, Phoenixin-14 (PNX-14) and Phoenixin-20 (PNX-20).
In the study of the evolution of nervous systems, SMIM20 together with NUCB2 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.
Excerpted from Wikipedia’s “SMIM20” article, available under the CC BY-SA 4.0 licence.