SMOC2
Sign in to saveAlso known as DTDP1, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1
SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.
Gene data
SMOC2- Name
- SPARC related modular calcium binding 2
- Type
- protein-coding
- Aliases
- DTDP1, DTDP1A, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
via MyGene.info
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/64094
- HomoloGene ID
- 11150
- genomic end
- 169073984
- genomic start
- 168841831
- cytogenetic location
- 6q27
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~1 min read
Article
3 sectionsContents
- Clinical relevance
- References
- Further reading
SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.
==Clinical relevance== This gene has been shown mutated in clinical cases of major dental developmental defects.