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GeneQ18045557· pop 5· linked from 4 articles

Also known as DTDP1, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1

SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.

Gene data

SMOC2
Name
SPARC related modular calcium binding 2
Type
protein-coding
Position
168,440,656–168,673,445 (+)
Aliases
DTDP1, DTDP1A, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1
RefSeq RNA
NM_001166412.2, NM_022138.3, XM_011536065.2, XM_011536066.2, XM_054356215.1
RefSeq protein
NP_001159884.1, NP_071421.1, XP_011534367.1, XP_011534368.1, XP_054212190.1

This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

via MyGene.info

Gene · Ensembl

SPARC related modular calcium binding 2

Symbol
SMOC2
Biotype
Protein coding
Organism
Homo sapiens
Location
6:168,440,656-168,673,445
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 9 more facts
HomoloGene ID
11150
genetic association
vitiligo
found in taxon
Homo sapiens
genomic end
169073984
genomic start
168841831
cytogenetic location
6q27
expressed in
myometrium
Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • Clinical relevance
  • References
  • Further reading

SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.

==Clinical relevance== This gene has been shown mutated in clinical cases of major dental developmental defects.

Excerpted from Wikipedia’s “SMOC2” article, available under the CC BY-SA 4.0 licence.

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