Also known as LARP3, La, La/SSB, Sjogren syndrome antigen B, small RNA binding exonuclease protection factor La
protein-coding gene in the species Homo sapiens
Gene data
SSB- Name
- small RNA binding exonuclease protection factor La
- Type
- protein-coding
- Position
- 169,791,933–169,812,091 (+)
- Aliases
- LARP3, La, La/SSB, SSB/La
- Ensembl
- ENSG00000138385
- RefSeq RNA
- NM_001294145.2, NM_003142.5
- RefSeq protein
- NP_001281074.1, NP_003133.1
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
small RNA binding exonuclease protection factor La
- Symbol
- SSB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:169,791,933-169,812,091
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SSB PDB 1owx.png
Show 9 more facts
- HomoloGene ID
- 2366
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6741
- genomic end
- 170668574
- genomic start
- 170648443
- chromosome
- human chromosome 2
- cytogenetic location
- 2q31.1
- different from
- single-sideband modulation
- expressed in
- anterior pituitary
Sources (4)
via Wikidata · CC0