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GeneQ18055229· pop 5· linked from 2 articles

ST8SIA6

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Also known as SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene.

Gene data

ST8SIA6

Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Type: protein-coding
Position: 17,315,416–17,454,681 (−)
Aliases: SIA8F, SIAT8-F, SIAT8F, ST8SIA-VI, ST8SiaVI
Ensembl: ENSG00000148488
RefSeq RNA: NM_001004470.3, NM_001345961.2, NR_144322.2, XM_017016174.2, XM_024447977.2
RefSeq protein: NP_001004470.1, NP_001332890.1, XP_016871663.1, XP_024303745.1, XP_024303746.1

This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].

Gene Ontology

Biological process

ganglioside biosynthetic process ganglioside biosynthetic process N-glycan processing protein O-linked glycosylation glycoprotein metabolic process glycoprotein metabolic process glycoprotein biosynthetic process glycolipid biosynthetic process

Molecular function

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity sialyltransferase activity sialyltransferase activity

Cellular component

Golgi membrane Golgi membrane

Pathways

Metabolism of proteins Sialic acid metabolism Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Asparagine N-linked glycosylation Synthesis of substrates in N-glycan biosythesis Post-translational protein modification Transport to the Golgi and subsequent modification N-glycan antennae elongation in the medial/trans-Golgi N-Glycan antennae elongation

via MyGene.info

Gene · Ensembl

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

Symbol: ST8SIA6
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:17,315,416-17,454,681
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 17112
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/338596
genomic end: 17454595
genomic start: 17315421
chromosome: human chromosome 10
cytogenetic location: 10p12.33
expressed in: white blood cell

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene.

==Function==

Excerpted from Wikipedia’s “ST8SIA6” article, available under the CC BY-SA 4.0 licence.

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