SUN2

Name

Sad1 and UNC84 domain containing 2

Type

protein-coding

Position

38,733,280–38,794,143 (−)

Aliases

UNC84B, rab5IP

Ensembl

ENSG00000100242

RefSeq RNA

NM_001199579.2, NM_001199580.2, NM_001394427.1, NM_001394428.1, NM_001394429.1

RefSeq protein

NP_001186508.1, NP_001186509.1, NP_001381356.1, NP_001381357.1, NP_001381358.1

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010].