SZT2
Sign in to saveAlso known as C1orf84, EIEE18, KIAA0467, SZT2A, SZT2B, seizure threshold 2 homolog (mouse), SZT2, KICSTOR complex subunit, SZT2 subunit KICSTOR complex
Seizure threshold 2 homolog is a protein that in humans is encoded by the SZT2 gene.
Gene data
SZT2- Name
- SZT2 subunit of KICSTOR complex
- Type
- protein-coding
- Position
- 43,389,882–43,454,247 (+)
- Aliases
- C1orf84, DEE18, EIEE18, KIAA0467, KICS1, SZT2A, SZT2B
- Ensembl
- ENSG00000198198
- RefSeq RNA
- NM_001012960.1, NM_001012961.1, NM_001365999.1, NM_015284.4, NM_182518.2
- RefSeq protein
- NP_001352928.1, NP_056099.3
The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SZT2 subunit of KICSTOR complex
- Symbol
- SZT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:43,389,882-43,454,247
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 49413
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23334
- genomic end
- 43454247
- genomic start
- 43855553
- chromosome
- human chromosome 1
- cytogenetic location
- 1p34.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Seizure threshold 2 homolog is a protein that in humans is encoded by the SZT2 gene.
== Function ==
Excerpted from Wikipedia’s “SZT2” article, available under the CC BY-SA 4.0 licence.