TBCE
Sign in to saveAlso known as HRD, KCS, KCS1, pac2, tubulin folding cofactor E, PEAMO
Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.
Gene data
TBCE- Name
- tubulin folding cofactor E
- Type
- protein-coding
- Position
- 235,367,360–235,452,443 (+)
- Aliases
- HRD, KCS, KCS1, PEAMO, pac2
- Ensembl
- ENSG00000284770
- RefSeq RNA
- NM_001079515.3, NM_001287801.2, NM_001287802.2, NM_003193.5
- RefSeq protein
- NP_001072983.1, NP_001274730.1, NP_001274731.1, NP_003184.1
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Wikidata facts
- Instance of
- gene
Show 4 more facts
- HomoloGene ID
- 37744
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6905
- cytogenetic location
- 1q42.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.
Excerpted from Wikipedia’s “TBCE” article, available under the CC BY-SA 4.0 licence.