TDP1
Sign in to saveAlso known as tyrosyl-DNA phosphodiesterase 1
Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.
Gene data
TDP1- Name
- tyrosyl-DNA phosphodiesterase 1
- Type
- protein-coding
- Position
- 89,954,939–90,044,820 (+)
- Ensembl
- ENSG00000042088
- RefSeq RNA
- NM_001008744.2, NM_001330205.2, NM_018319.4, XM_005267848.4, XM_006720197.5
- RefSeq protein
- NP_001008744.1, NP_001317134.1, NP_060789.2, XP_005267905.1, XP_006720260.1
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
tyrosyl-DNA phosphodiesterase 1
- Symbol
- TDP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:89,954,939-90,044,820
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of Type I topoisomerase and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks.
Excerpted from Wikipedia’s “TDP1” article, available under the CC BY-SA 4.0 licence.