TGM3
Sign in to saveAlso known as TGE, transglutaminase 3, UHS2
Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene.
Gene data
TGM3- Name
- transglutaminase 3
- Type
- protein-coding
- Position
- 2,295,994–2,341,177 (+)
- Aliases
- TGE, UHS2
- Ensembl
- ENSG00000125780
- RefSeq RNA
- NM_003245.4
- RefSeq protein
- NP_003236.3
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
transglutaminase 3
- Symbol
- TGM3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:2,295,994-2,341,177
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TGM3 PDB 1l9m.png
Show 9 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 20690
- genetic association
- basal-cell carcinoma of the skin
- exact match
- identifiers.org/ncbigene/7053
- genomic start
- 2276647
- chromosome
- human chromosome 20
- genomic end
- 2341079
- cytogenetic location
- 20p13
- expressed in
- granulocyte
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene.
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.
Excerpted from Wikipedia’s “TGM3” article, available under the CC BY-SA 4.0 licence.