thiadiazoles
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In chemistry, thiadiazoles are a sub-family of azole compounds, with the name thiadiazole originating from the Hantzsch–Widman nomenclature. Structurally, they are five-membered heterocyclic compounds containing one sulfur and two nitrogen atoms. The ring is aromatic by virtue of the two double bonds and one of the lone pairs of electrons of sulfur. Four constitutional isomers are possible, differing by the relative positions of the sulfur and nitrogen atoms. The nomenclature thus includes the locations of each of those three atoms, with the first of the three numbers referring to the sulfur.
Research
16,688 papers- 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses.Acta pharmaceutica (Zagreb, Croatia) · 2020
- 1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.European journal of medicinal chemistry · 2015
- Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade.Molecules (Basel, Switzerland) · 2022
- Medicinal chemistry and properties of 1,2,4-thiadiazoles.Mini reviews in medicinal chemistry · 2005
- Synthetic and Biological Aspects of Thiadiazoles and their Condensed Derivatives: An Overview.Current topics in medicinal chemistry · 2016
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In chemistry, thiadiazoles are a sub-family of azole compounds, with the name thiadiazole originating from the Hantzsch–Widman nomenclature. Structurally, they are five-membered heterocyclic compounds containing one sulfur and two nitrogen atoms. The ring is aromatic by virtue of the two double bonds and one of the lone pairs of electrons of sulfur. Four constitutional isomers are possible, differing by the relative positions of the sulfur and nitrogen atoms. The nomenclature thus includes the locations of each of those three atoms, with the first of the three numbers referring to the sulfur.
The parent compounds are rarely synthesized and possess no particular application, however, compounds bearing them as a structural motif are fairly common in pharmacology. Of them, 1,3,4-thiadiazole is the most common, appearing in such medications as cephazolin and acetazolamide.
Excerpted from Wikipedia’s “thiadiazoles” article, available under the CC BY-SA 4.0 licence.