Thiazepines
Sign in to savethumb|right|130px|1,3-thiazepine thumb|right|130px|1,4-thiazepine thumb|Diltiazem. 1,4-thiazepine is the seven membered ring in the middle. Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine.
Research
5,145 papers- Synthesis of Pyrido-annelated Diazepines, Oxazepines and Thiazepines.Current medicinal chemistry · 2016
- Vasopeptidase inhibitors.Lancet (London, England) · 2001
- Synthesis and anti-proliferative activity evaluation of novel benzo[d][1,3] dioxoles-fused 1,4-thiazepines.European journal of medicinal chemistry · 2017
- Marine pyrroloiminoquinone alkaloids.Topics in current chemistry · 2012
- Novel multitarget directed ligands inspired by riluzole: A serendipitous synthesis of substituted benzo[b][1,4]thiazepines potentially useful as neuroprotective agents.Bioorganic & medicinal chemistry · 2024
via PubMed
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Encyclopedic overview
2 sectionsContents
- References
- External links
thumb|right|130px|1,3-thiazepine thumb|right|130px|1,4-thiazepine thumb|Diltiazem. 1,4-thiazepine is the seven membered ring in the middle. Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine.
Benzothiazepines have a single benzene attached to the ring, while dibenzothiazepines have two. Diltiazem, a benzothiazepine, is a calcium channel blocker intermediate in properties between verapamil and the dihydropyridines. It is used to treat variant angina (Prinzmetal's angina), either naturally occurring or drug-induced and stable angina.
Excerpted from Wikipedia’s “Thiazepines” article, available under the CC BY-SA 4.0 licence.