TIMP1

Also known as CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a two-domain glycoprotein with a molecular weight of 28 kDa. TIMP1 is expressed in several tissues of organisms.

Gene data

TIMP1

Name: TIMP metallopeptidase inhibitor 1
Type: protein-coding
Chromosome: X
Position: 47,582,227–47,586,793 (+)
Aliases: CLGI, EPA, EPO, HCI, TIMP, TIMP-1
Ensembl: ENSG00000102265
RefSeq RNA: NM_003254.3
RefSeq protein: NP_003245.1

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008].

Pathways

HIF-1 signaling pathway - Homo sapiens (human)Hemostasis Platelet degranulation Cytokine Signaling in Immune system Degradation of the extracellular matrix Extracellular matrix organization Activation of Matrix Metalloproteinases Signal Transduction Immune System Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

via MyGene.info

Gene · Ensembl

TIMP metallopeptidase inhibitor 1

Symbol: TIMP1
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr X:47,582,227-47,586,793
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~3 min read

Encyclopedic overview

8 sections

Contents

Function
Cell-surface receptor binding
Other names
Regulation of TIMP expression
See also
References
Further reading
External links

This protein is a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.

Excerpted from Wikipedia’s “TIMP1” article, available under the CC BY-SA 4.0 licence.