Skip to content
Vinony
English
EnglishDeutschEspañolFrançaisItalianoNederlandsPortuguêsSvenskaالعربية
GeneQ18041427· pop 5· linked from 2 articles

TIPIN

Sign in to save

Also known as TIMELESS interacting protein

TIMELESS-interacting protein (TIPIN) is a protein that in humans is encoded by the TIPIN gene.

Gene data

TIPIN
Name
TIMELESS interacting protein
Type
protein-coding
Position
66,336,191–66,386,756 (−)
Ensembl
ENSG00000075131
RefSeq RNA
NM_001289986.2, NM_001398281.1, NM_001398282.1, NM_001398283.1, NM_001398284.1
RefSeq protein
NP_001276915.1, NP_001385210.1, NP_001385211.1, NP_001385212.1, NP_001385213.1

The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].

Gene Ontology

Pathways

DNA Double-Strand Break RepairHomology Directed RepairHDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)Processing of DNA double-strand break endsDNA Repair

via MyGene.info

Gene · Ensembl

TIMELESS interacting protein

Symbol
TIPIN
Biotype
Protein coding
Organism
Homo sapiens
Location
15:66,336,191-66,386,756
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
32373
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/54962
chromosome
human chromosome 15
genomic start
66336191
genomic end
66679084
cytogenetic location
15q22.31
expressed in
sperm
Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

6 sections
Contents
  • Structure
  • Function
  • Interactions
  • Clinical significance
  • References
  • Further reading

TIMELESS-interacting protein (TIPIN) is a protein that in humans is encoded by the TIPIN gene.

== Structure == TIPIN is a relatively small protein that lacks known enzymatic activity and functions primarily through protein-protein interactions. It forms a stable complex with TIMELESS, a binding interaction that is essential for its role in the replication stress response. Crystallographic and structural studies have confirmed direct interactions between TIPIN, TIMELESS, and other components of the replication machinery.

Excerpted from Wikipedia’s “TIPIN” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0