TMEM123
Sign in to saveAlso known as KCT3, PORIMIN, PORMIN, transmembrane protein 123
Porimin is a protein that in humans is encoded by the TMEM123 gene.
Gene data
TMEM123- Name
- transmembrane protein 123
- Type
- protein-coding
- Position
- 102,396,329–102,470,384 (−)
- Aliases
- KCT3, PORIMIN, PORMIN
- Ensembl
- ENSG00000152558
- RefSeq RNA
- NM_052932.3
- RefSeq protein
- NP_443164.2
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
transmembrane protein 123
- Symbol
- TMEM123
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:102,396,329-102,470,384
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 14177
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/114908
- chromosome
- human chromosome 11
- genomic start
- 102267063
- genomic end
- 102341115
- cytogenetic location
- 11q22.2
- expressed in
- ganglionic eminence
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Porimin is a protein that in humans is encoded by the TMEM123 gene.
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins.
Excerpted from Wikipedia’s “TMEM123” article, available under the CC BY-SA 4.0 licence.