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GeneQ18038783· pop 6· linked from 4 articles

TNRC6A

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Also known as CAGH26, GW1, GW182, TNRC6, trinucleotide repeat containing 6A, FAME6, trinucleotide repeat containing adaptor 6A

Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene.

Gene data

TNRC6A

Name: trinucleotide repeat containing adaptor 6A
Type: protein-coding
Position: 24,610,209–24,827,632 (+)
Aliases: CAGH26, FAME6, GW1, GW182, TNRC6
Ensembl: ENSG00000090905
RefSeq RNA: NM_001330520.3, NM_001351850.2, NM_014494.4, XM_005255257.5, XM_017023144.3
RefSeq protein: NP_001317449.1, NP_001338779.1, NP_055309.2, XP_005255314.1, XP_016878633.1

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

P-body assembly miRNA-mediated post-transcriptional gene silencing miRNA-mediated post-transcriptional gene silencing miRNA processing miRNA-mediated gene silencing by inhibition of translation miRNA-mediated gene silencing by inhibition of translation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Molecular function

nucleic acid binding RNA binding protein binding protein-macromolecule adaptor activity

Cellular component

P-body P-body P-body P-body nucleoplasm cytosol cytosol RISC complex

Pathways

PIP3 activates AKT signaling Developmental Biology Adaptive Immune System Cell-Cell communication Cell-Cell communication Signaling by NOTCH Signal Transduction MTOR signalling Immune System Organelle biogenesis and maintenance

via MyGene.info

Gene · Ensembl

trinucleotide repeat containing adaptor 6A

Symbol: TNRC6A
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:24,610,209-24,827,632
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

2 sections

Contents

References
Further reading

Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene.

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.

Excerpted from Wikipedia’s “TNRC6A” article, available under the CC BY-SA 4.0 licence.

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