TPD52L1

Also known as D53, hD53, tumor protein D52-like 1, tumor protein D52 like 1, TPD52 like 1, TPD53

Tumor protein D52 is a protein that in humans is encoded by the TPD52L1 gene.

Gene data

TPD52L1

Name: TPD52 like 1
Type: protein-coding
Position: 125,119,049–125,264,407 (+)
Aliases: D53, TPD53
Ensembl: ENSG00000111907
RefSeq RNA: NM_001003395.3, NM_001003396.3, NM_001003397.3, NM_001292026.3, NM_001300994.3
RefSeq protein: NP_001003395.1, NP_001003396.1, NP_001003397.1, NP_001278955.1, NP_001287923.1

This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016].

Gene Ontology

Biological process

G2/M transition of mitotic cell cycle G2/M transition of mitotic cell cycle positive regulation of MAP kinase activity positive regulation of JNK cascade positive regulation of JNK cascade positive regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway

Molecular function

protein binding identical protein binding protein homodimerization activity

Cellular component

cytoplasm cytoplasm perinuclear region of cytoplasm

Pathways

Membrane Trafficking trans-Golgi Network Vesicle Budding Golgi Associated Vesicle Biogenesis Vesicle-mediated transport

via MyGene.info

Gene · Ensembl

TPD52 like 1

Symbol: TPD52L1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:125,119,049-125,264,407
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Tumor protein D52 is a protein that in humans is encoded by the TPD52L1 gene.

== Function == This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.

Excerpted from Wikipedia’s “TPD52L1” article, available under the CC BY-SA 4.0 licence.

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