TRIM23

Also known as ARD1, ARFD1, RNF46, tripartite motif containing 23

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

Gene data

TRIM23

Name: tripartite motif containing 23
Type: protein-coding
Position: 65,587,492–65,625,975 (−)
Aliases: ARD1, ARFD1, RNF46
Ensembl: ENSG00000113595
RefSeq RNA: NM_001656.4, NM_033227.3, NM_033228.3, XM_017009444.3, XM_047417155.1
RefSeq protein: NP_001647.1, NP_150230.1, NP_150231.1, XP_016864933.1, XP_047273111.1

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008].