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GeneQ18033480· pop 6· linked from 3 articles

TSC22D1

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Also known as Ptg-2, TGFB1I4, TSC22, TSC22 domain family member 1

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.

Gene data

TSC22D1

Name: TSC22 domain family member 1
Type: protein-coding
Position: 44,432,143–44,577,433 (−)
Aliases: HUCEP-2, Ptg-2, TGFB1I4, TSC22
Ensembl: ENSG00000102804
RefSeq RNA: NM_001243797.2, NM_001243798.2, NM_001243799.1, NM_006022.4, NM_183422.4
RefSeq protein: NP_001230726.1, NP_001230727.1, NP_001230728.1, NP_006013.1, NP_904358.2

This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of cell population proliferation positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of programmed cell death

Molecular function

transcription coactivator activity protein binding identical protein binding

Cellular component

nucleus nucleus nucleus nucleus nucleus cytoplasm cytoplasm cytoplasm

Pathways

Ectoderm Differentiation

via MyGene.info

Gene · Ensembl

TSC22 domain family member 1

Symbol: TSC22D1
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:44,432,143-44,577,433
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 7573
exact match: identifiers.org/ncbigene/8848
genetic association: vasculitis
found in taxon: Homo sapiens
genomic end: 45151283
genomic start: 45007655
chromosome: human chromosome 13
cytogenetic location: 13q14.11

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.

TSC22 encodes a transcription factor and belongs to the large family of early response genes.

Excerpted from Wikipedia’s “TSC22D1” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0