Structure via PubChem · Public domain (PubChem)
U0126
Sign in to saveAlso known as (2Z,3Z)-bis[amino(sulfanyl)methylidene]butanedinitrile, U-0126, U 0126
U0126 is a MEK1/2 inhibitor that is used to study MEK and related signaling pathways. This inhibitor is selective for both MEK1 and MEK2, two specific types of MEK (MAPK kinases) that are elements of the MAPK/ERK signaling pathway. This compound is usually studied in the context of cancer treatment, ischemia, and cellular oxidative stress.
Chemical data
- Formula
- C18H16N6S2
- Molecular weight
- 380.5 g/mol
- IUPAC name
- (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
- SMILES
- C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
- InChIKey
- DVEXZJFMOKTQEZ-JYFOCSDGSA-N
- XLogP
- 2
- Polar surface area
- 202 Ų
- H-bond donors
- 4
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 380.08778651200004
Show 4 more facts
- chemical formula
- C₁₈H₁₆N₆S₂
- isomeric SMILES
- Nc1ccccc1S\C(N)=C(C#N)\C(C#N)=C(/N)Sc1ccccc1N
- canonical SMILES
- c1ccc(c(c1)N)SC(=C(C#N)C(=C(N)Sc2ccccc2N)C#N)N
- Commons category
- U0126
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
U0126 is a MEK1/2 inhibitor that is used to study MEK and related signaling pathways. This inhibitor is selective for both MEK1 and MEK2, two specific types of MEK (MAPK kinases) that are elements of the MAPK/ERK signaling pathway. This compound is usually studied in the context of cancer treatment, ischemia, and cellular oxidative stress.
The compound is not approved by the FDA as a therapeutic agent, and is primarily used in preclinical research settings. This compound is available for research purposes from a number of companies.
Excerpted from Wikipedia’s “U0126” article, available under the CC BY-SA 4.0 licence.