UBAP1

Also known as NAG20, UAP, UBAP, UBAP-1, ubiquitin associated protein 1, SPG80

Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.

Gene data

UBAP1

Name: ubiquitin associated protein 1
Type: protein-coding
Position: 34,179,005–34,252,523 (+)
Aliases: NAG20, SPG80, UAP, UBAP, UBAP-1
Ensembl: ENSG00000165006
RefSeq RNA: NM_001171201.1, NM_001171202.1, NM_001171203.3, NM_001171204.3, NM_016525.5
RefSeq protein: NP_001164672.1, NP_001164673.1, NP_001164674.1, NP_001164675.1, NP_057609.2

This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].

Gene Ontology

Biological process

multivesicular body assembly ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway membrane fission

Molecular function

protein binding ubiquitin binding ubiquitin binding ubiquitin binding

Cellular component

ESCRT I complex ESCRT I complex ESCRT I complex ESCRT I complex cytoplasm endosome endosome cytosol

Pathways

HIV Life Cycle Budding and maturation of HIV virion Late Phase of HIV Life Cycle HIV Infection Disease Membrane binding and targetting of GAG proteins Synthesis And Processing Of GAG, GAGPOL Polyproteins Assembly Of The HIV Virion Membrane Trafficking Vesicle-mediated transport

via MyGene.info

Gene · Ensembl

ubiquitin associated protein 1

Symbol: UBAP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:34,179,005-34,252,523
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

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Contents

References
Further reading

Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.

This gene is a member of the ubiquitin-associated domain (UBA) family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin-binding domain consisting of a compact three-helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Truncating Mutations in UBAP1 Cause Hereditary Spastic Paraplegia.

Excerpted from Wikipedia’s “UBAP1” article, available under the CC BY-SA 4.0 licence.

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