UIMC1
Sign in to saveAlso known as RAP80, X2HRIP110, ubiquitin interaction motif containing 1
BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.
Gene data
UIMC1- Name
- ubiquitin interaction motif containing 1
- Type
- protein-coding
- Position
- 176,902,225–177,022,646 (−)
- Aliases
- RAP80, X2HRIP110
- Ensembl
- ENSG00000087206
- RefSeq RNA
- NM_001199297.3, NM_001199298.2, NM_001317961.2, NM_016290.5, NR_146149.2
- RefSeq protein
- NP_001186226.1, NP_001186227.1, NP_001304890.1, NP_057374.3, XP_005265987.1
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ubiquitin interaction motif containing 1
- Symbol
- UIMC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:176,902,225-177,022,646
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 9455
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51720
- genomic end
- 176449634
- genomic start
- 176332006
- chromosome
- human chromosome 5
- cytogenetic location
- 5q35.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Repair of DNA damage
- References
- Further reading
BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.
==Repair of DNA damage==
Excerpted from Wikipedia’s “UIMC1” article, available under the CC BY-SA 4.0 licence.