United States at the 2012 Summer Olympics

The United States of America (USA), represented by the United States Olympic Committee (USOC), competed at the 2012 Summer Olympics in London, from July 27 to August 12, 2012. U.S. athletes have competed at every Summer Olympic Games in the modern era, except the 1980 Summer Olympics in Moscow which they boycotted in protest of the Soviet invasion of Afghanistan. The USOC sent a total of 530 athletes to the Games, 262 men and 268 women, to compete in 25 sports. For the first time in its Olympic history, the United States was represented by more female than male athletes.

U.S. athletes left London with a total of 105 medals (48 gold, 26 silver and 31 bronze), finishing at the top of the gold and overall medal standings. The 48-gold medal record was the most the United States had ever won in any Olympics in which it was not the host nation. At least one medal was awarded to U.S. athletes in sixteen sports, thirteen of which contained at least one gold. U.S. athletes dominated the nations' medal standings in swimming, wherein they won a total of 31 medals, including 16 golds. Twenty-seven U.S. athletes won more than a single medal. The U.S. team-based athletes also proved particularly successful, as the women's soccer, water polo, and volleyball teams won gold and silver medals, respectively. Furthermore, the men's and women's basketball teams managed to defend their titles from Beijing. For the first time since 1936, no U.S. athlete won an Olympic medal in sailing.