VAPA
Sign in to saveAlso known as VAP-33, VAP-A, VAP33, hVAP-33, VAMP associated protein A, VAMP-A
VAMP-Associated Protein A ( or Vesicle-Associated Membrane Protein-Associated Protein A) is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes.
Gene data
VAPA- Name
- VAMP associated protein A
- Type
- protein-coding
- Aliases
- VAMP-A, VAP-33, VAP-A, VAP33, hVAP-33
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
VAMP associated protein A
- Symbol
- VAPA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:9,913,916-9,960,021
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein VAPA PDB 1z9l.png
Show 5 more facts
- HomoloGene ID
- 37824
- exact match
- identifiers.org/ncbigene/9218
- genomic start
- 9914016
- genomic end
- 9960018
- cytogenetic location
- 18p11.22
Sources (4)
via Wikidata · CC0
~4 min read
Article
10 sectionsContents
- Protein structure
- Intracellular Localisation
- Interactions
- Vesicle traffic and fusion
- Viral Proteins
- FFAT motif
- Function
- Associated Diseases
- References
- Further reading
VAMP-Associated Protein A ( or Vesicle-Associated Membrane Protein-Associated Protein A) is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes.
VAPA is ubiquitously expressed in human tissues and is thought to be involved in membrane trafficking by interaction with SNAREs, in regulation of lipid transport and metabolism, and in the Unfolded Protein Response (UPR).