VAV3
Sign in to saveAlso known as vav guanine nucleotide exchange factor 3
Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.
Gene data
VAV3- Name
- vav guanine nucleotide exchange factor 3
- Type
- protein-coding
- Position
- 107,571,161–107,965,275 (−)
- Ensembl
- ENSG00000134215
- RefSeq RNA
- NM_001079874.2, NM_006113.5, XM_005270360.3, XM_005270361.2, XM_017000053.2
- RefSeq protein
- NP_001073343.1, NP_006104.4, XP_005270417.1, XP_005270418.1, XP_016855542.1
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
vav guanine nucleotide exchange factor 3
- Symbol
- VAV3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:107,571,161-107,965,275
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- See also
- References
- Further reading
Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Excerpted from Wikipedia’s “VAV3” article, available under the CC BY-SA 4.0 licence.