VPS35

Also known as MEM3, PARK17, VPS35 retromer complex component, VPS35, retromer complex component

gene umano

Gene data

VPS35

Name: VPS35 retromer complex component
Type: protein-coding
Position: 46,656,132–46,689,518 (−)
Aliases: MEM3, PARK17
Ensembl: ENSG00000069329
RefSeq RNA: NM_018206.6, XM_005256045.4, XM_011523227.4, XM_054313466.1, XM_054313467.1
RefSeq protein: NP_060676.2, XP_005256102.1, XP_011521529.1, XP_054169441.1, XP_054169442.1

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008].