VPS4B
Sign in to saveAlso known as SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B
Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.
Gene data
VPS4B- Name
- vacuolar protein sorting 4 homolog B
- Type
- protein-coding
- Position
- 63,389,190–63,422,483 (−)
- Aliases
- DTDP1B, MIG1, SKD1, SKD1B, VPS4-2
- Ensembl
- ENSG00000119541
- RefSeq RNA
- NM_004869.4, XM_047437949.1, XM_054319378.1
- RefSeq protein
- NP_004860.2, XP_047293905.1, XP_054175353.1
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein VPS4B PDB 1wr0.png
Show 5 more facts
- HomoloGene ID
- 37976
- exact match
- identifiers.org/ncbigene/9525
- genomic end
- 61089716
- genomic start
- 61056423
- cytogenetic location
- 18q21.33
Sources (3)
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- Further reading
Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.