WFDC1
Sign in to saveAlso known as PS20, WAP four-disulfide core domain 1
WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.
Gene data
WFDC1- Name
- WAP four-disulfide core domain 1
- Type
- protein-coding
- Position
- 84,294,615–84,329,853 (+)
- Aliases
- PS20
- Ensembl
- ENSG00000103175
- RefSeq RNA
- NM_001282466.2, NM_001282467.2, NM_021197.4, XM_047434411.1, XM_054313565.1
- RefSeq protein
- NP_001269395.1, NP_001269396.1, NP_067020.2, XP_047290367.1, XP_054169540.1
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
WAP four-disulfide core domain 1
- Symbol
- WFDC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:84,294,615-84,329,853
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 10920
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/58189
- genomic end
- 84329844
- genomic start
- 84294846
- chromosome
- human chromosome 16
- cytogenetic location
- 16q24.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.
Excerpted from Wikipedia’s “WFDC1” article, available under the CC BY-SA 4.0 licence.