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GeneQ18038116· pop 7· linked from 7 articles

WIPI2

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Also known as ATG18B, Atg21, WIPI-2, CGI-50, WD repeat domain, phosphoinositide interacting 2, IDDSSA

WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene.

Gene data

WIPI2
Name
WD repeat domain, phosphoinositide interacting 2
Type
protein-coding
Position
5,190,182–5,233,855 (+)
Aliases
ATG18B, Atg21, CGI-50, IDDSSA, WIPI-2
Ensembl
ENSG00000157954
RefSeq RNA
NM_001033518.2, NM_001033519.2, NM_001033520.1, NM_001278299.2, NM_015610.4
RefSeq protein
NP_001028690.1, NP_001028691.1, NP_001028692.1, NP_001265228.1, NP_056425.1

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008].

Gene Ontology

Pathways

Autophagy - other - Homo sapiens (human)Autophagy - animal - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Huntington disease - Homo sapiens (human)Spinocerebellar ataxia - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Shigellosis - Homo sapiens (human)MacroautophagyAutophagy

via MyGene.info

Gene · Ensembl

WD repeat domain, phosphoinositide interacting 2

Symbol
WIPI2
Biotype
Protein coding
Organism
Homo sapiens
Location
7:5,190,182-5,233,855
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
90887
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/26100
genomic end
5233840
genomic start
5190196
chromosome
human chromosome 7
cytogenetic location
7p22.1
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections
Contents
  • Function
  • See also
  • References
  • Further reading

WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene.

== Function ==

Excerpted from Wikipedia’s “WIPI2” article, available under the CC BY-SA 4.0 licence.

Available in 7 languages

via Wikidata sitelinks · CC0