YTHDF2

Name

YTH N6-methyladenosine RNA binding protein F2

Type

protein-coding

Position

28,736,608–28,770,214 (+)

Aliases

CAHL, DF2, HGRG8, NY-REN-2

Ensembl

ENSG00000198492

RefSeq RNA

NM_001172828.2, NM_001173128.2, NM_016258.3

RefSeq protein

NP_001166299.1, NP_001166599.1, NP_057342.2

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

via MyGene.info

Gene · Ensembl

YTH N6-methyladenosine RNA binding protein F2

Symbol

YTHDF2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:28,736,608-28,770,214

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0