ZIC2
Sign in to saveAlso known as HPE5, Zic family member 2
Zinc finger protein ZIC2 is a protein that in humans is encoded by the ZIC2 gene. ZIC2 is a member of the Zinc finger of the cerebellum (ZIC) protein family.
Gene data
ZIC2- Name
- Zic family zinc finger 2
- Type
- protein-coding
- Position
- 99,981,266–99,986,765 (+)
- Aliases
- HPE5
- Ensembl
- ENSG00000043355
- RefSeq RNA
- NM_007129.5
- RefSeq protein
- NP_009060.2
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Zic family zinc finger 2
- Symbol
- ZIC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:99,981,266-99,986,765
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Zinc finger protein ZIC2 is a protein that in humans is encoded by the ZIC2 gene. ZIC2 is a member of the Zinc finger of the cerebellum (ZIC) protein family.
== Function ==
Excerpted from Wikipedia’s “ZIC2” article, available under the CC BY-SA 4.0 licence.