ZXDC
Sign in to saveAlso known as ZXDL, ZXD family zinc finger C
Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II. For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein. ZXDC is activated by sumoylation, a post-translational modification. ZXDC plays a role in controlling immunological responses, cancer formation and progression, and cell proliferation, differentiation, and survival.
Gene data
ZXDC- Name
- ZXD family zinc finger C
- Type
- protein-coding
- Aliases
- ZXDL
Enables C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Involved in positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 82340
- exact match
- identifiers.org/ncbigene/79364
- genomic end
- 126475891
- genomic start
- 126156444
- cytogenetic location
- 3q21.3
Sources (3)
via Wikidata · CC0
~6 min read
Article
7 sectionsContents
- History
- Structure
- Function
- Isolation
- Role in disease
- References
- External links
Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II. For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein. ZXDC is activated by sumoylation, a post-translational modification. ZXDC plays a role in controlling immunological responses, cancer formation and progression, and cell proliferation, differentiation, and survival.
== History ==