ZXDC
Sign in to saveAlso known as ZXDL, ZXD family zinc finger C
Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II. For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein. ZXDC is activated by sumoylation, a post-translational modification. ZXDC plays a role in controlling immunological responses, cancer formation and progression, and cell proliferation, differentiation, and survival.
Gene data
ZXDC- Name
- ZXD family zinc finger C
- Type
- protein-coding
- Position
- 126,436,365–126,476,022 (−)
- Aliases
- ZXDL
- Ensembl
- ENSG00000070476
- RefSeq RNA
- NM_001040653.4, NM_025112.5, NR_104249.2, XM_005247757.4, XM_006713741.3
- RefSeq protein
- NP_001035743.1, NP_079388.3, XP_005247814.1, XP_006713804.1, XP_011511421.1
Enables C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Involved in positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
ZXD family zinc finger C
- Symbol
- ZXDC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:126,436,365-126,476,022
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 82340
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79364
- genomic end
- 126475891
- genomic start
- 126156444
- chromosome
- human chromosome 3
- cytogenetic location
- 3q21.3
Sources (3)
via Wikidata · CC0
~6 min read
Encyclopedic overview
7 sectionsContents
- History
- Structure
- Function
- Isolation
- Role in disease
- References
- External links
Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II. For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein. ZXDC is activated by sumoylation, a post-translational modification. ZXDC plays a role in controlling immunological responses, cancer formation and progression, and cell proliferation, differentiation, and survival.
== History ==
Excerpted from Wikipedia’s “ZXDC” article, available under the CC BY-SA 4.0 licence.