EC 1.13.11

Lipoxygenases () (LOX) are a family of (non-heme) iron-containing enzymes, more specifically oxidative enzymes, most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4-pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.

mammalian protein found in Homo sapiens

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mammalian protein found in Homo sapiens

InterPro Family

3-hydroxyanthranilate 3,4-dioxygenase () is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction

InterPro Family

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Dioxygenases are oxidoreductase enzymes. Aerobic life, from simple single-celled bacteria species to complex eukaryotic organisms, has evolved to depend on the oxidizing power of dioxygen in various metabolic pathways. From energetic adenosine triphosphate (ATP) generation to xenobiotic degradation, the use of dioxygen as a biological oxidant is widespread and varied in the exact mechanism of its use. Enzymes employ many different schemes to use dioxygen, and this largely depends on the substrate and reaction at hand.

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mammalian protein found in Homo sapiens

InterPro Family

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enzyme

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InterPro Family

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obsolete enzyme family

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